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INSTITUT UNIVERSITAIRE DU GOLFE DE GUINEE
INSTITUT SUPERIEUR DES SCIENCES APPLIQUEES
ETIOLOGICAL PROFILE AND ANTIMICROBIAL SUSCEPTIBILITY
PATTERN OF URINARY TRACT INFECTIONS AMONG PATIENTS ATTENDING THE DISTRICT
HOSPITAL OF NYLON
This is done in partial fulfilment of the
Higher National Diploma (HND)
Speciality: Medical Laboratory Studies
(MLST)
Written by:
MATUE DIPANDA Colette R.
Matricule; 411C170266
Supervisor:
Mr SAMA FONKENG L.
(Masters in Clinical Biochemistry)
Academic year 2019/2020
CERTIFICATION
This memory is my original work and has not been presented for
the award of a Higher National Diploma in this university.
MATUE DIPANDA Colette .R
Department of Health science IUG
Date.....................................
Signature.................................
SUPERVISOR'S APPROVAL
This memory has been submitted for examination with my full
approval as a university
Mr SAMA FONKENG L.
(Masters in Clinical Biochemistry)
Department of Health science IUG
Date.............................................
Signature..........................................
DEDICATION
To
My lovely mother TAGNE Uguette
ACKNOWLEDGEMENTS
I wish to express my sincere gratitude to;
· The almighty GOD for the gift of life, strength and
wisdom,
· The proprietor of this institution Mr. Louis-Marie
DJAMBOU for this opportunity to be trained by putting in place this
institution.
· The director of ISA Mrs. WAKO Roslette.
· My supervisor Mr. SAMA Leonard for his invaluable
support and scholarly advice towards my work from its inception.
· I am greatly indebted to the entire staff of ISA and
the staff of the District Hospital of Nylon for their guidance throughout my
study, as well as to their patients.
· I wish to express my sincere gratitude to Mrs. EKOBO
Crescence who was available when I needed any guide.
· Likewise special recognition goes to the families;
TAGNE, DIPANDA, DEUKO, TSIMI and my lovely grandfather TAGNE Jean De Dieu for
their support.
· . The understanding and support I received from my
friends; MADEFEU, FONKEM, YANGO, CHANGEH and my classmates cannot be
overemphasized. Thank you to all that participated near or far to this work
ABSTRACT
Introduction: Urinary tract infection (UTI)
is the pathological invasion of the urinary tract by microorganisms. It poses a
major public health problem in terms of morbidity and financial cost. UTI is
considered as one of the most common bacterial infections acquired in the
community and in hospitals. It may be asymptomatic, acute, chronic, and its
clinical manifestations depend on the portion of the urinary tract involved,
the etiologic organisms, the severity of the infection, and the patient's
ability to mount an immune response to it. Both asymptomatic and symptomatic
UTIs possesses a serious threat to public health care, hence reducing the
quality of life. This study aim to determine uropathogens causing UTIs and
their susceptibility pattern to common antimicrobial drugs among patients
attending the DHN. Method: To achieve this, information on the
patients were collected from the laboratory register of 2019 (December to
June). These data was then analyzed using the software Graph Part version 20.1
and the Chi square test was used to compare variable. Results:
of the 248 participants, 79.03% were females whereas 20.97% were males.
Patients of age between 21-30 and 1-10 were more prevalent while patients of
71-80 been less represented. E.coli was the most infectious
uropathogen (31.45%) follow by Staphyloccocus Sp (27.02%). Multiple
or mix infection was common with E coli and Candidas (2.42%).
Males were more infected with Klebsiella Sp, Proteus Sp,
Staphyloccocus SP, while females were more infected with
E.Coli, Providencia Stuartii and C. albicans. High
prevalence was observed in the age ranges [21-30] (29.84%), [1-10]
(18.95%),[31-40] (16.53%) and [11-20] (10.08%) respectively. The repartition
of microorganism according to their susceptibility to classes of antimicrobial
drugsshows that Candida albicans was more sensible both in azole
(75.00%) and polyenes (58.33%). E. coli was more sensitive to Macrolides
(78.21%) whereas it was more resistant to cephalosporine (55.13%), penicillin
(84.62%), Fluoroquinolones (68.57%) and Carbapenem (58.97%).
Conclusion: This study reveals a familiar pattern with respect
to the uropathogens involved in UTIs with the principal cause being
gram-negative bacteria, E. coli and Klebsiella spas the
leading ones. However gram positive bacteria were also among the etiology with
Staphylococcus sp being the leading one and fungi as well. This study
alsoshowed considerable bacterial resistance to common empirically prescribed
antimicrobial drugs.
Keys words: UTIs, Uropathogens,
susceptibility profile.
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