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Gastrointestinal infections and under nutrition among children between 0 and 5 years old. Case of Mareba sector, Bugesera district, eastern province, Rwanda


par Wilson NSENGIYUMVA
Kigali institute of Rwanda (KIE) - Licence 2012
  

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II.6.1.1. Balanced diet for children

To avoid malnutrition, a balanced diet is one that has adequate daily servings from each of the food groups (energy giving food, protein giving food, vitamin and mineral giving food) and provides adequate nutrition for growth, and good health, both physical and mental. The source of energy includes mainly rice, wheat, cassava, bananas, sweet potatoes, bread to supply metabolic demands. The source of proteins include beans, cassava leaves, meat, fish and eggs and contain all essential amino acids to build organism such as in muscles. The source of essential fatty acids include the vegetable seed oils to protect organism against diseases. The source of micronutrients (vitamins and mineral elements) includes the dark green leaves, red and white meats for many biochemical reactions in the body. These groups of food must be found in the daily diet of children. The age of child is the determining factor in portion sizes and amount of each food group recommended (RIDHS, 2005). Breastfeeding a baby for at least six months is considered the best way to prevent early-childhood malnutrition.

Talking to a doctor before putting a child on any kind of diet, such as vegan, vegetarian, or low-carbohydrate, can help assure that the child gets the full supply of nutrients that he or she needs (Brookes, 1999). In society where the prevalence of malnutrition is high, sugar, cooking oil, maize flour and wheat flour could be potential vehicles for delivering vitamins and minerals.

ll.6.2. How malnutrition decrease immune system and lead to gastrointestinal infections?

The first line of defense against these types of infection is the innate (non specific) immune response, particularly epithelial barriers and the mucosal immune response. Protein Malnutrition (PM) significantly compromises mucosal epithelial barriers in the gastrointestinal, respiratory and urogenital tracts. For example, vitamin A, protein, micronutrients deficiencies induce the loss of mucus-producing cells. This loss of the protective mucus blanket increases susceptibility to infection by pathogens that would ordinarily be trapped in the mucus and swept away by the cleansing flow of mucus out of the body. Malnourished children suffer in greater proportion from bacterial gastrointestinal and respiratory infections (Chandra, 1999).

The human body requires a balanced diet that provides nutrients, minerals, and vitamins for a functional and effective immune response. Immune function is impacted by factors including hormonal status, age, and nutritional status. Malnutrition results in a depressed immune system that raises the risk of infections (Hedlund, 1995).

Severe PM in newborns and small children has been shown to cause atrophy of the thymus with reduced cell numbers and subsequently ill-developed peripheral lymphoid organs, i.e., lymph nodes and spleen. Malnourished children suffer in greater proportion from respiratory infections, infectious diarrhea, and malaria, characterized by a protracted course and exacerbated disease. These malnourished children present with diminished functional T cell counts, increased undifferentiated lymphocyte numbers, and depressed serum complement activity (Savino, 2002).

Several studies on the effects of malnutrition at the immunological level have been conducted in humans and in experimental animal models. Multiple immune system abnormalities, including lymphoid organ atrophy, profound T-cell deficiency, altered ratios of T-cell subsets, and decreased natural killer (NK) cell activity and cytokine production have been described in individuals. In addition, these studies indicate that malnutrition decreases T-cell function, cytokine production and the ability of lymphocytes to respond appropriately to cytokines (Bhaskaram, 1992).

As shown in figure 2, nutritional deficiencies can affect immune response and increase susceptibility to infections. In turn, infection further aggravates nutritional deficiencies by increasing metabolic demands, decreasing nutrient intake, or blocking absorption from the gut (Calder et al., 2002). Nutritional and dietary supplements stimulate immune response and may result in fewer infections, particularly in the elderly and in malnourished, critically ill individuals (Chandra, 1999).

Figure 2: Relationship between nutrition and infection. Adapted from (Brown, 2003).

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