3.2.6 Quinolines solutions
Chloroquine, quinine and quinidine stock solutions (0.02 M)
were prepared by dissolving 51.6 mg, 32.4 mg and 78.3 mg of them, respectively,
in 25 mL of acidic distilled water, completed with addition of equivalent
volume of propylene glycol.
0.1 M tris (hydroxymethyl)-methylamine was used as buffer for
all solutions.
3.2.7 Artemisinin solutions
In 40% DMSO aqueous solutions, artesunate, dihydroartemisinin
and artemisinin stock solutions (0.002 M) were prepared by dissolving 19.2 mg,
14.2 mg and 14.1mg of them, respectively, in 10 mL of DMSO, completed with
addition of 15 mL of buffer.
In DMSO solutions, artesunate, dihydroartemisinin and
artemisinin stock solutions (2 mM) were prepared by dissolving 7.69 mg, 5.69
mg and 5.65 mg of them, respectively, in 10 mL of DMSO (for HPLC-MS
measurements).
In 50% propylene glycol solutions, artesunate stock solution
(0.002 M) was prepared by first dissolving19.2 mg of it in 12.5 mL of 5 %
sodium bicarbonate, followed by addition of equivalent volume of propylene
glycol.
|
