ANNEXE 4: Application des cellules souches en medecine
regeneratrice et titulaires des droits de propriete industrielle.
IP
Owners
Tools
Sperm donor
Docyte dcnor
Derivation
·
· Cell fusion
· Media & factors Culture supports Genetic erg.
Eml;rCells yEnic Stem
..sNeurons
I!
Patient
· Gerona/ WARF
· Univ. of California
· Univ of Carnlaidge
Merck
Stakeholders
§ Gamete donors
· Patient advocacy Toup:s
|
Propegiatkm
|
· Media & fat.l.ogN
· Culture supports
· Genetic Eng.
|
|
Directed
Diffarentation
Media & factors
· Culture supports
· Genetic erg.
· Drugs
§ Scaffolds
· Tissue encr
Figme 1. Many technical stages of
embryonic stem cell R&D regiire many tools, each of which may have
different owners and stakeholders. Foto- key methodological stages are
delineated, and examples of disparate owners & stakeholders are
correspondingly labeled in color. This schematic only illustrates one
application cistern cells in regenerative medicine.
La technologie des cellules souches repose stir de nombreuses
&apes techniques elles-memes impliquant divers outils de recherche dont les
droits appartiennent a differents titulaires. Quatre &apes methodologiques
principales sont illustrees dans ce schema, des exemples de titualaires de
brevets fondateurs sont indiques..'
ANNEXE 5:Les 50 premieres organisations &tenant des
brevets sur les cellules souches delivres aupres de 1'USPTO.
Les institutions publiques sont en gras, Les entreprises
&tenant des portefeuilles communs avec les entreprises
|
listees par fusions et acquisitions sont indiquees entre
parentheses.
|
|
|
|
OrganIzal ion
|
Locallon
|
U.S. Palen's
|
Share
|
|
1
|
Arrigen {ImmurEc, Atgerix, Tu
|
Thousand Oaks, CA
|
51
|
3.0%
|
|
2
|
Nyeartis{S}pierntc, Neurositeres, Chiron)
|
easel, SAllrerland
|
47
|
27%
|
|
3
|
uniwer5i ol .:alifornia
|
....alciand. CA
|
46
|
2.7'1.
|
|
.1
|
Uniwersi ty or Mic hlga n
|
Ann ArbDr. roi
|
3F
|
2.191.
|
|
curt. TrIECECIallICS
|
Eatrricre, MD
|
22
|
1.9%
|
|
6
|
universi ly of Southern California
|
Los Angeles. CA
|
26
|
1.651.
|
|
7
|
Johns Hopkins university
|
Baillinae. roo
|
26
|
1.5'1.
|
|
u.s. Governmeni iNhij
|
eei hesda. mo
|
25
|
1.5'1.
|
|
9
|
The General Hospital C orporal ion
|
Boston. me.
|
24
|
1.4'1.
|
|
10
|
Pfizer (GO Searle, PriErnaria
|
New York, NY
|
23
|
1.3%
|
|
11
|
Stryker Corriccalion
|
Kakarnaz cc, MI
|
22
|
1.3%
|
|
12
|
Cal11. a nia Insii 11.11 e of Tec
hnolog!.
·
|
Pasadona. CA
|
20
|
1251.
|
|
13
|
GlexoSmIhKiine {Culler Pharr-a, CortKe)
|
laeniford, UK
|
16
|
1.0%
|
|
14
|
SIanlultlUnIversily
|
Palo All o. CA
|
16
|
1.0'1.
|
|
15
|
universi hi of Min nesol a
|
minneatKii. MN
|
14
|
0.351.
|
|
16
|
Bailor College of Medic ine
|
Houston. TX
|
13
|
0.851.
|
|
17
|
Geron Corporation
|
merio Park, OA
|
13
|
0.8%
|
|
16
|
Sloan-KO ering institute for Cancer Researc h
|
New York. NY
|
13
|
0.891.
|
|
Massac hmetts institute of Technology
|
Cambridge. ra.
|
12
|
0.79E
|
|
20
|
Wisconsin Alumni Research Foundation
|
madison. vii
|
12
|
0.7%
|
|
21
|
ONlagen
|
an CE1I43, CA
|
11
|
0.6%
|
|
22
|
Genentech
|
San Frati;co, CA
|
11
|
0.6%
|
|
23
|
Oelectech
|
Eatontown, NJ
|
11
|
0.6%
|
|
24
|
Univers! ry of Texas
|
Austin. I X.
|
II
|
0.691.
|
|
25
|
Case liVeslern Reserve Universily
|
Cleveland. Ohio
|
10
|
0.69L
|
|
26
|
Columbia Universily
|
New York. NY
|
10
|
0.691.
|
|
27
|
Fred Hutchinson Cancer Research Gen ter
|
Seal I le. 'NA
|
10
|
0.691.
|
|
28
|
ty of Pilisburgh
|
PI tl.burgh. PA
|
10
|
0.691.
|
|
29
|
Harvard Universily
|
Cambridge. me,
|
9
|
0.594.
|
|
30
|
Human Gencrne Sciences
|
Rxic.ville, MD
|
9
|
0.5%
|
|
31
|
Inllgen
|
DEFccesi, WI
|
9
|
05%
|
|
GIlI Ii' anal insilluk.
|
1010n10. Canada
|
9
|
0.551.
|
|
33
|
StemCals (Cylolherapeullcs)
|
Paki Alta, CA
|
9
|
0.5%
|
|
homas Jefferson Universily
|
Philadelphia. PA.
|
9
|
0.551.
|
|
35
|
UnNersi hi or Massac husellS
|
Ainnersi. MA
|
9
|
0.551.
|
|
36
|
Wyelh [Genetics
|
Maclson, NJ
|
9
|
0.5%
|
|
&Kim, Dickinson and Compaq
|
FrartilinLates, NJ
|
a
|
0.5%
|
|
Bel n Israel Deaconess Medical C en! er
|
eosi on . r.v..
|
8
|
0551.
|
|
39
|
Children's Medical Center Corporation
|
eosl on . me,
|
8
|
0.551.
|
|
40
|
Nal Iona! Jewish Center
|
Denver. CO
|
8
|
0351.
|
|
41
|
Pr 'melon Universily
|
Pr iric eion. NJ
|
8
|
0.551.
|
|
42
|
Stem Cell Tectnciagies
|
vanctuver, Canada
|
a
|
0.5%
|
|
43
|
Uniwersi ty or Edinburgh
|
Edinburgh. UK
|
8
|
0.55.
|
|
44
|
Univers! ry of Washingion
|
Seal I le. '01A
|
$
|
0.551.
|
|
kivance<ITKsueSciEnces
|
La Jc4la, CA
|
7
|
0.4%
|
|
46
|
12aXIEC iniernallonoi {CEIVD)
|
oecnien, IL
|
7
|
0.4%
|
|
47
|
Cedars Sinai Medical C eni er
|
Los Angeles. CA
|
7
|
0.4'1.
|
|
4.I3
|
Cell Genesys
|
San Frenelso], CA
|
7
|
0.4%
|
|
49
|
Cornell Poseirc h F oundal Ion
|
II haca. Prr
|
7
|
0.451.
|
|
50
|
Curls ferealiveeiardEcuies)
|
Cambridge, MA
|
7
|
0.4%
|
|
Olher
|
|
%8
|
56.1%
|
|
Tcial
|
|
1724
|
ii:o.o%
|
| 
