3.1.3 Physical chemical properties of used solvents
Some physical and chemical properties of solvents
which are used to study hemin-antimalarial drugs interactions are summarized on
the Table 3-1.
Table 3-1:
Comparison of physical, chemical and spectroscopic properties of water, DMSO
and propylene glycol (PREG) (Marcus, 1999).
|
Water
|
DMSO
|
PREG
|
|
Molecular weight (g.mol-1) :
|
18.02
|
78.13
|
76.10
|
|
Density at 25oC(g.cm-3) :
|
0.9974
|
1.0958
|
1.0326
|
|
Melting point ( oC) :
|
0.00
|
18.55
|
-60.15
|
|
Boiling point (oC) :
|
100.00
|
189.05
|
187.65
|
|
Surface tension at 25oC :
|
71.8
|
43.0
|
36.5
|
|
Viscosity at 25oC( mPa s) :
|
0.8903
|
1.991
|
42.2
|
|
Dielectric constant at 25oC :
|
78.36
|
46.45
|
32
|
|
Diameter (nm) :
|
0.343
|
0.513
|
0.533
|
|
Dipole momemt (D)
|
1.85
|
4.06
|
2.25
|
|
Hydrogen bond
donation ability :
|
1.17
|
0.00
|
0.83
|
|
Electron -pair donicity :
|
0.47
|
0.76
|
0.78
|
|
Polarity / polarizability :
|
1.09
|
1.00
|
0.76
|
|
Proton affinity (KJ mol-1) :
|
697
|
834
|
828
|
|
PKa at 25oC :
|
-
|
-
|
14.80
|
|
PKb at 25oC :
|
-
|
15.5
|
-
|
|
Spectroscopic windows, UV(nm) :
|
190
|
265
|
-
|
|
